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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP3A
All Species:
36.06
Human Site:
T384
Identified Species:
52.89
UniProt:
Q13472
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13472
NP_004609.1
1001
112372
T384
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
Chimpanzee
Pan troglodytes
XP_511323
1001
112378
T384
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
Rhesus Macaque
Macaca mulatta
XP_001095437
1001
112278
T384
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
Dog
Lupus familis
XP_546656
989
110956
T384
T
V
L
V
E
Q
Q
T
P
D
P
R
W
G
A
Cat
Felis silvestris
Mouse
Mus musculus
O70157
1003
112340
T384
V
A
L
V
E
Q
Q
T
V
D
P
H
W
G
A
Rat
Rattus norvegicus
XP_002742497
1001
111922
X384
X
X
X
X
X
X
X
X
X
X
X
X
W
G
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510142
1042
116269
T427
V
A
L
V
Q
Q
Q
T
Q
D
Q
H
W
G
D
Chicken
Gallus gallus
NP_001025807
1020
114626
T386
S
A
L
V
Q
H
Q
T
Q
D
P
N
W
G
A
Frog
Xenopus laevis
NP_001085699
1022
114003
T389
T
S
L
V
E
Q
Q
T
H
D
P
Q
W
G
G
Zebra Danio
Brachydanio rerio
XP_688695
998
112490
T382
T
R
L
V
E
Q
Q
T
Q
D
Q
E
W
G
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9NG98
1250
136119
T378
A
P
L
V
E
M
Q
T
G
H
R
D
W
G
A
Honey Bee
Apis mellifera
XP_394050
958
109977
I352
I
S
L
V
N
Q
Q
I
N
N
P
A
W
G
N
Nematode Worm
Caenorhab. elegans
O61660
759
85420
R197
Q
T
L
H
L
R
N
R
F
R
D
L
L
G
Q
Sea Urchin
Strong. purpuratus
XP_782119
679
77025
V117
A
R
A
A
D
V
L
V
I
W
T
D
C
D
R
Poplar Tree
Populus trichocarpa
XP_002307047
910
102138
S342
Y
P
R
T
E
T
D
S
F
S
S
R
T
D
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201197
926
103389
T364
R
A
M
V
E
E
Q
T
R
H
P
A
W
G
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.9
87.7
N.A.
86.8
83.8
N.A.
72.8
73
70.9
66.5
N.A.
41.2
46.8
38.5
47
Protein Similarity:
100
99.6
97
91.1
N.A.
91.5
88.9
N.A.
80.5
82.9
81.8
80.3
N.A.
53.7
63.7
50.8
57
P-Site Identity:
100
100
100
100
N.A.
73.3
20
N.A.
53.3
60
73.3
66.6
N.A.
53.3
46.6
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
73.3
20
N.A.
60
73.3
80
66.6
N.A.
53.3
53.3
20
6.6
Percent
Protein Identity:
40
N.A.
N.A.
38.8
N.A.
N.A.
Protein Similarity:
56.3
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
66.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
13
25
7
7
0
0
0
0
0
0
0
13
0
0
50
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
0
0
0
0
7
0
7
0
0
57
7
13
0
13
7
% D
% Glu:
0
0
0
0
63
7
0
0
0
0
0
7
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
7
0
0
0
0
88
7
% G
% His:
0
0
0
7
0
7
0
0
7
13
0
13
0
0
0
% H
% Ile:
7
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
75
0
7
0
7
0
0
0
0
7
7
0
7
% L
% Met:
0
0
7
0
0
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
7
0
7
0
7
7
0
7
0
0
13
% N
% Pro:
0
13
0
0
0
0
0
0
25
0
57
0
0
0
0
% P
% Gln:
7
0
0
0
13
57
75
0
19
0
13
7
0
0
7
% Q
% Arg:
7
13
7
0
0
7
0
7
7
7
7
32
0
0
7
% R
% Ser:
7
13
0
0
0
0
0
7
0
7
7
0
0
0
7
% S
% Thr:
38
7
0
7
0
7
0
69
0
0
7
0
7
0
0
% T
% Val:
13
25
0
75
0
7
0
7
7
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
7
0
0
82
0
0
% W
% Tyr:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _